Enhancement of Antitumor Activity of Cisplatin on Human Gastric Cancer Cellsin vitroandin vivoby Buthionine Sulfoximine
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Assessment of Antitumor Activity of Vinca herbacea on Human Ovarian Cancer Cell Line
Background: It seems that Vinca. herbacea has an anti-tumor effect. Here, the immunotherapeutic effect of this compound is assessed against human ovarian cancer (SKOV3) cells because of the high incidence of this tumor in women. Materials and Methods: The cytotoxic activity of V. herbacea extract against human ovarian cancer (SKOV3) cells was determined by MTT assay. The apoptosis-inducing pote...
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Chemotherapy failure remains a significant medical problem in the treatment of neoplastic disease and is thought to be due to many different factors including membrane transport, p-glycoprotein in multidrug resistance, glutathione and its related enzymes, topoisomerase II and DNA repair. Glutathione is a major constituent of non-protein thiol and participates in detoxification of chemotherapy a...
متن کاملButhionine sulfoximine diverts the melanogenesis pathway toward
23 Buthionine sulfoximine (BSO) is a specific inhibitor of γ-glutamylcysteine synthetase, thus 24 blocking the synthesis of glutathione (GSH). It is known that this makes that BSO affects melanin 25 synthesis because of the role of thiols in melanogenesis. However, BSO may also react with the 26 intermediate oxidation products of melanogenesis, a possibility that has not been investigated from ...
متن کاملEnhancement of arsenic trioxide-induced apoptosis in HeLa cells by diethyldithiocarbamate or buthionine sulfoximine.
Arsenic trioxide (ATO) affects many biological functions such as cell proliferation, apoptosis, differentiation and angiogenesis in various cells. We investigated the in vitro effects of ATO as a reactive oxygen species (ROS) generator or a glutathione (GSH) depletor on apoptosis in HeLa cells. ATO decreased the viability of HeLa cells in a dose-dependent manner with an IC50 of approximately 5-...
متن کاملPotent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
Buthionine sulfoximine (S-n-butyl homocysteine sulfoximine), the most potent of a series of analogs of methionine sulfoximine thus far studied (Griffith, O.W., Anderson, M.E., and Meister, A. (1979) J. Biol. Chem. 254, 1205-1210), inhibited gamma-glutamylcysteine synthetase about 20 times more effectively than did prothionine sulfoximine and at least 100 times more effectively than methionine s...
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1993
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1993.tb02045.x